Obesity

The first clinical trial comparing semaglutide and tirzepatide, two popular, injectable weight-loss drugs, has been published, examining their ability to reduce weight and waist circumference. And one clearly comes out on top.

Following on from a remarkable study in mice, scientists have now confirmed that silencing a certain protein in muscle tissue leads to energy-deprived human cells seeking out fat for fuel, while blocking the body's ability to store extra fat cells.

The first once-daily oral GLP-1 medication could be on shelves by this time next year, making the weight-loss drug easier to take and potentially cheaper. In the race to be the first, Novo Nordisk has scored a huge win, while Pfizer has failed again.

If you're among the half of US adults who have tried to lose weight in the last year, you'll know how enthusiasm wanes when you hit the inevitable "plateau." New research shows that this is an adjustment period, and long-term success is over the hill.

Extracts made from parts of the cashew plant that are usually thrown away when the nuts are processed commercially were found to significantly limit the development of fat cells and the accumulation of fat, according to new research.

It was only a matter of time until the GLP-1 receptor agonist drugs like Ozempic and Wegovy were superseded, and now it looks like we'll have the next generation of these breakthrough weight loss and diabetes medicines on shelves by early next year.

Men tend to be happier with life when they're married, as many studies have identified over the last few decades. But new research shows they also become fatter. In fact, they're three times more likely to be obese than men who remained unmarried.

Researchers at the University of Cambridge have identified a bunch of genes linked to obesity in dogs – and found the very same ones in humans predisposed to putting on weight too.

Hitting a plateau after a steady run of weight loss has derailed many health and fitness plans. But what if you could flick a biological switch to nix plateaus and speed up metabolism? Scientists may have found the key – and it was by complete accident.

Scientists in China have found a new potential drug target for weight loss. Blocking a protein called CD44 has been shown to protect against obesity in mice on a high-fat diet, specifically by suppressing the formation of white fat cells.

Skipping one night of sleep causes healthy adults to see a spike in immune cells linked to chronic inflammation, a key feature of obesity, according to new research. It highlights the powerful link between sleep and immune health.

Researchers at Columbia University Irving Medical Center have identified the specific neurons in mice brains that tell them they've eaten enough. This fascinating discovery could play a big role in the future of weight loss treatments for humans.